Understanding the Ramifications of Switching Among AEDs: A 2008 Clinical Update
The contents of this issue of University of Tennessee Advanced Studies in Pharmacy include 3 review articles and a roundtable discussion.
Activity Date: July 2008  — Activity Info: Volume5, (5)
Goals & Objectives | Faculty | Complete Pre-Test Activity | Introduction | Full Activity Content | CME Test & Evaluation (CME Expired)


To provide pharmacists with up-to-date information on the ramifications of switching among antiepileptic drugs.

This activity is designed for pharmacists involved in formulary decisions and prescribing or monitoring of antiepileptic drugs. No prerequisites required.

The University of Tennessee College of Pharmacy takes responsibility for the content, quality, and scientific integrity of this CE activity. At the conclusion of this activity, the participant should be able to:

  • Describe the US Food and Drug Administration’s standards and requirements for generic drugs and the positions of national societies.
  • List the challenges and concerns regarding substitution with generic antiepileptic drugs (AEDs) in terms of bioequivalence, narrow therapeutic index, and risk versus benefit.
  • Analyze historical and newer data on the effects of switching among AEDs, in addition to patient and clinician experiential research to justify a possible switch to a generic.
  • Compare and contrast current issues in AED substitution, including future research, epilepsy management, quality of life, risk of breakthrough seizures, and alteration of brand drugs.

The University of Tennessee College of Pharmacy (UTCOP) is accredited by the Accreditation Council of Pharmacy Education (ACPE) to provide continuing education for pharmacists.

ACPE LogoThis program is sponsored by The University of Tennessee College of Pharmacy who is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Successful completion of this program will provide 2 contact hours credit (0.2 CEUs). Successful completion includes reading the materials, completing the post-test with a score of at least 70%, and completing the program evaluation. If you score less than 70% on the post-test, you will be allowed to complete the post-test 1 more time. A statement of CE credit will be available online immediately following successful completion of the program. ACPE program #064-000-08-203-H04-P.

This continuing education activity was produced under the supervision of Glen E. Farr, PharmD, Associate Dean of Continuing Pharmacy Education, University of Tennessee College of Pharmacy.

The estimated time to complete this educational activity: 2 hours.

Release date: July 15, 2008. Expiration date: July 15, 2010.

The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of The University of Tennessee College of Pharmacy name implies review of educational format, design, and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings, and adverse effects, before administering pharmacologic therapy to patients.

A participant, sponsor, faculty member, or other individual wanting to file a grievance with respect to any aspect of a program sponsored or cosponsored by the UTCOP may contact the Associate Dean for Continuing Education in writing. The grievance will be reviewed and a response will be returned within 45 days of receiving the written statement. If not satisfied, an appeal to the Dean of the College of Pharmacy can be made for a second level of review.

This program is supported by an educational grant from Ortho-McNeil Neurologics, administered by Ortho-McNeil Janssen Scientific Affairs.

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